The G6PD Benefit: Beyond Oxidative Stress
G6PD is often discussed in the context of deficiencies, but the real story is in the high-activity variants found in centenarian populations. Higher G6PD activity directly correlates with increased glutathione production and a robust defense against oxidative stress. It is a strategic longevity benefit.
The Klotho Factor
Klotho is a pleiotropic protein that regulates everything from insulin sensitivity to calcium homeostasis. Low levels are linked to accelerated aging and cognitive decline. Genomics reveals that 2.4% of the population is at a distinct disadvantage—but identification is the first step toward intervention.